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AM-2394

Catalog No: 16122855
CAS Number: 1442684-77-6
Purity: 98% 

AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. 

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Chemical Information

NameAM-2394
Iupac Chemical NameAM-2394 
SynonymsAM 2394; AM2394 
Molecular FormulaC22H25N5O4 
Molecular Weight423.473 
InChiKey
InChi
CAS Number1442684-77-6
Related CAS

Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122855 - AM-2394 | CAS 1442684-77-6

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