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AKT inhibitor VIII Catalog No : 161009020

Chemical Information

Product NameAKT inhibitor VIII
Iupac Chemical Name3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one 
SynonymsAKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730 
Molecular FormulaC34H29N7O 
Molecular Weight551.65 
SmileC1(=CC=CC=C1)C=1C(=NC=2C=C3C(=CC2N1)N=CN3)C3=CC=C(C=C3)CN3CCC(CC3)N3C(NC1=C3C=CC=C1)=O
InChiKeyBIWGYFZAEWGBAL-UHFFFAOYSA-N
InChiInChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)
Cas612847-09-3

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

AKT inhibitor VIII suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells. AKT inhibitor VIII displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, for example, calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase. 

Chemical Structure

161009020 - AKT inhibitor VIII | CAS 612847-09-3

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