AFN-1252
Catalog No: 17021406
CAS Number: 620175-39-5
Purity: 98%
AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of 0.12 g/ml.
AFN-1252 was inactive (MIC90, >4 g/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.
For research use only. We do not sell to patients.
Chemical Information
| Name | AFN-1252 |
|---|---|
| Iupac Chemical Name | AFN-1252 |
| Synonyms | API-1252; Debio 1452 |
| Molecular Formula | C₂₂H₂₁N₃O₃ |
| Molecular Weight | 375.42 |
| Smile | Cc1c2ccccc2oc1CN(C)C(=O)/C=C/c3cc4c(nc3)NC(=O)CC4 |
| InChiKey | QXTWSUQCXCWEHF-JXMROGBWSA-N |
| InChi | InChI=1S/C22H21N3O3/c1-14-17-5-3-4-6-18(17)28-19(14)13-25(2)21(27)10-7-15-11-16-8-9-20(26)24-22(16)23-12-15/h3-7,10-12H,8-9,13H2,1-2H3,(H,23,24,26)/b10-7+ |
| CAS Number | 620175-39-5 |
| MDL | MFCD18633190 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
