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AFN-1252

Catalog No.: 17021406
Cas No.: 620175-39-5
Purity : 98% 
17021406 - AFN-1252 | CAS 620175-39-5

Catalog number : 17021406

CAS number : 620175-39-5

Molecular Formula : C₂₂H₂₁N₃O₃ 

Molecular Weight : 375.42 

Iupac Chemical Name : AFN-1252 

Smile : Cc1c2ccccc2oc1CN(C)C(=O)/C=C/c3cc4c(nc3)NC(=O)CC4

InChiKey : QXTWSUQCXCWEHF-JXMROGBWSA-N

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SynonymsAPI-1252; Debio 1452 
Molecular FormulaC₂₂H₂₁N₃O₃ 
Molecular Weight375.42 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCc1c2ccccc2oc1CN(C)C(=O)/C=C/c3cc4c(nc3)NC(=O)CC4
InChiKeyQXTWSUQCXCWEHF-JXMROGBWSA-N
InChiInChI=1S/C22H21N3O3/c1-14-17-5-3-4-6-18(17)28-19(14)13-25(2)21(27)10-7-15-11-16-8-9-20(26)24-22(16)23-12-15/h3-7,10-12H,8-9,13H2,1-2H3,(H,23,24,26)/b10-7+
MDLMFCD18633190
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AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of 0.12 g/ml.

AFN-1252 was inactive (MIC90, >4 g/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.

 

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