AER-271
AER-271 is a potent aquaporin-4 (AQP4) inhibitor. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Treatment with AER-271 ameliorated early cerebral edema measured at 3 h after CA vs vehicle treated rats. This treatment also attenuated early NDS. In contrast to rats treated with vehicle after CA, rats treated with AER-271 did not develop significant neuronal death or neuroinflammation as compared to sham.
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Chemical Information
| Name | AER-271 |
|---|---|
| Iupac Chemical Name | 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate |
| Synonyms | AER-271; AER 271; AER271; |
| Molecular Formula | C15H9ClF6NO5P |
| Molecular Weight | 463.6532 |
| Smile | O=P(O)(OC1=CC=C(Cl)C=C1C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)O |
| InChiKey | WSHXPHFIHYXZKC-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H9ClF6NO5P/c16-9-1-2-12(28-29(25,26)27)11(6-9)13(24)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6H,(H,23,24)(H2,25,26,27) |
| CAS Number | 634913-39-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Farr GW, Hall CH, Farr SM, Wade R, Detzel JM, Adams AG, Buch JM, Beahm DL,
Flask CA, Xu K, LaManna JC, McGuirk PR, Boron WF, Pelletier MF. Functionalized
Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving
Outcome in Two Models of CNS Injury. Neuroscience. 2019 Apr 15;404:484-498. doi:
10.1016/j.neuroscience.2019.01.034. Epub 2019 Feb 7. PubMed PMID: 30738082;
PubMed Central PMCID: PMC6495193.
2: Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR,
Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD. The
aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early
outcome in a pediatric model of asphyxial cardiac arrest. Pediatr Res. 2019
Mar;85(4):511-517. doi: 10.1038/s41390-018-0215-5. Epub 2018 Oct 26. PubMed PMID:
30367162; PubMed Central PMCID: PMC6397683.
3: Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes
RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA.
Operation Brain Trauma Therapy: 2016 Update. Mil Med. 2018 Mar
1;183(suppl_1):303-312. doi: 10.1093/milmed/usx184. PubMed PMID: 29635589.
Chemical Structure
