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Inhibitors&Agonists
Angiogenesis
Anti-infection
Apoptosis
Autophagy
Cell Cycle
Cytoskeleton
DNA Damage
Epigenetics
GPCR & G Protein
Immunology & Inflammation
JAK/STAT
MAPK
Membrane Transporter/Ion Channel
Metabolism
Neuronal Signaling
NF-κB
Protein Tyrosine Kinase
Proteases
PI3K/Akt/mTOR
Stem Cells & Wnt
TGF-beta/Smad
Ubiquitin
Vitamin D Related
PROTAC
Antibody-drug Conjugate/ADC Related
Microbiology
Others
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Amino Acids
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52750 - AEE788
AEE788
编号: 52750
Cas号: 497839-62-0
纯度: 98%
AEE788(NVP-AEE 788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKC and CDK1.
For research use only. We do not sell to patients.
化学信息
名称
AEE788
分子式
C27H32N6
分子量
440.58
Smile
CCN1CCN(CC1)Cc2ccc(cc2)c3cc-4c(nc[nH]c4n3)N[C@H](C)c5ccccc5
InChiKey
FZKTWZZPPTUYSG-GQJKKZBQSA-N
InChi
InChI=1S/C27H40N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,20,24-31H,3,13-19H2,1-2H3/t20-,24?,25?,26?,27?/m1/s1
Cas号
497839-62-0
MDL
MFCD11100351
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技术数据
质量控制
生物活性
参考文献
纯度
98%
可溶性
DMSO 88 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
Handling
HS Code
Coming soon.
Targets
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Cell study
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Clinical study
Not available
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