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ABT888

Catalog No.: 17022801
Cas No.: 912445-05-7
Purity : 98% 
17022801 - ABT888 | CAS 912445-05-7

Catalog number : 17022801

CAS number : 912445-05-7

Molecular Formula : C₁₃H₁₈Cl₂N₄O 

Molecular Weight : 317.21 

Iupac Chemical Name : ABT888 

Smile : C[C@@H]1CCNC1c2[nH]c3cccc(c3n2)C(=O)N

InChiKey : FXRVOXLVQCUUGN-PVSHWOEXSA-N

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SynonymsABT-888 dihydrochloride; ABT888 dihydrochloride; ABT 888 dihydrochloride 
Molecular FormulaC₁₃H₁₈Cl₂N₄O 
Molecular Weight317.21 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC[C@@H]1CCNC1c2[nH]c3cccc(c3n2)C(=O)N
InChiKeyFXRVOXLVQCUUGN-PVSHWOEXSA-N
InChiInChI=1S/C13H16N4O/c1-7-5-6-15-10(7)13-16-9-4-2-3-8(12(14)18)11(9)17-13/h2-4,7,10,15H,5-6H2,1H3,(H2,14,18)(H,16,17)/t7-,10?/m1/s1
MDLMFCD12031514
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Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.

ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 with K(i)s of 5.2 and 2.9 nmol/L, respectively. The compound has good oral bioavailability and crosses the blood-brain barrier [1]. ABT-888 displayed excellent potency against both the PARP-1 and PARP-2 enzymes with a K(i) of 5 nM and in a C41 whole cell assay with an EC(50) of 2 nM [2]. ABT-888 reduced clonogenic survival in H460 lung cancer cells, and inhibited DNA repair as shown by enhanced expression of DNA strand break marker histone gamma-H2AX.

 

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