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ABT-639

Catalog No.: 6111011
Cas No.: 1235560-28-7
Purity : 98% 

ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 M) and attenuates LVA currents in rat DRG neurons (IC50 = 8 M).

ABT-639 is significantly less active at other Ca2+ channels (e.g. Cav1.2 and Cav2.2) (IC50 > 30 M). ABT-639 has high oral bioavailability (%F = 73), low protein binding (88.9%) and a low brain:plasma ratio (0.05:1) in rodents.



 

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Chemical Information

NameABT-639
Iupac Chemical NameABT-639 
SynonymsABT639; ABT 639 
Molecular FormulaC20H20ClF2N3O3S 
Molecular Weight455.91 
InChiKey
InChi
CAS Number1235560-28-7
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

6111011 - ABT-639 | CAS 1235560-28-7

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