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AB-680

Catalog No.: 2091501
Cas No.: 2105904-82-1
Purity : 98% Min.

AB-680 is highly potent, reversible and selective CD73 inhibitor. AB680 to be a reversible, slow-onset competitive inhibitor of human CD73 with a Ki of 5 pM. Clinical candidates of this potency are uncommon and deserve special consideration during lead optimization. AB680 is the first small molecule CD73 inhibitor in the clinic. 

For research use only. We do not sell to patients.

Chemical Information

NameAB-680
Iupac Chemical Name(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid
SynonymsAB-680 ; AB 680 ; AB680 ;
Molecular FormulaC20H24ClFN4O9P2
Molecular Weight 580.8269
SmileO=P(CP(O)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1
InChiKeyMFYLCAMJNGIULC-KCVUFLITSA-N
InChi InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1
CAS Number2105904-82-1
Related CAS2105904-82-1

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
TargetsCD73 inhibitor
Mechanism
Cell study
Animal study
Clinical study

1: Bowman CE, da Silva RG, Pham A, Young SW. An Exceptionally Potent Inhibitor of
Human CD73. Biochemistry. 2019 Aug 6;58(31):3331-3334. doi:
10.1021/acs.biochem.9b00448. Epub 2019 Jul 23. PubMed PMID: 31334635.

Chemical Structure

2091501 - AB-680 | CAS 2105904-82-1

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