AB-680
Catalog No: 2091501
CAS Number: 2105904-82-1
Purity: 98% Min.
AB-680一种是高效、可逆和选择性CD73抑制剂。 AB-680是第一个临床使用的CD73抑制剂。
For research use only. We do not sell to patients.
Chemical Information
| Name | AB-680 |
|---|---|
| Iupac Chemical Name | (((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid |
| Synonyms | AB-680 ; AB 680 ; AB680 ; |
| Molecular Formula | C20H24ClFN4O9P2 |
| Molecular Weight | 580.8269 |
| Smile | O=P(CP(O)(O)=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1 |
| InChiKey | MFYLCAMJNGIULC-KCVUFLITSA-N |
| InChi | InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1 |
| CAS Number | 2105904-82-1 |
| Related CAS | 2105904-82-1 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| Solubility | 可溶于DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| HS Code |
Coming soon.
| Targets | CD73 inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Bowman CE, da Silva RG, Pham A, Young SW. An Exceptionally Potent Inhibitor of
Human CD73. Biochemistry. 2019 Aug 6;58(31):3331-3334. doi:
10.1021/acs.biochem.9b00448. Epub 2019 Jul 23. PubMed PMID: 31334635.
Chemical Structure
