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A2793

Catalog No: 20286
CAS Number: 88349-90-0
Purity: 98% Min.

A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). A2793 inhibited TWIK-related acid-sensitive K+ channel (TASK)-1 (100 µM, 53.4% ± 13, 5%, n = 5).

For research use only. We do not sell to patients.

Chemical Information

NameA2793
Iupac Chemical NameEthyl 2-[(5-chloroquinolin-8-yl)oxy]acetate
SynonymsA2793; A-2793; A2793;
Molecular FormulaC13H12ClNO3
Molecular Weight265.69
SmileO=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1
InChiKeyJEMXUSHXYOXNFL-UHFFFAOYSA-N
InChiInChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3
CAS Number88349-90-0
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Lengyel M, Erdélyi F, Pergel E, Bálint-Polonka Á, Dobolyi A, Bozsaki P, Dux M, Király K, Hegedűs T, Czirják G, Mátyus P, Enyedi P. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12. PMID: 30979812.

2: Bosman WM, Bronkhorst MW. Een vrouw met een pijnlijke enkel [A woman with a painful ankle]. Ned Tijdschr Geneeskd. 2012;156(4):A2793. Dutch. PMID: 22278033.

3: Oehlmann M, Score AJ, Blow JJ. The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol. 2004 Apr 26;165(2):181-90. doi: 10.1083/jcb.200311044. Epub 2004 Apr 19. PMID: 15096526; PMCID: PMC2172031.

4: Prokhorova TA, Blow JJ. Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity. J Biol Chem. 2000 Jan 28;275(4):2491-8. doi: 10.1074/jbc.275.4.2491. PMID: 10644704; PMCID: PMC3626232.


Chemical Structure

20286 - A2793 | CAS 88349-90-0

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