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A-1210477

Catalog No.: 17022404
Cas No.: 1668553-26-1
Purity : 98% 
17022404 - A-1210477 | CAS 1668553-26-1

Catalog number : 17022404

CAS number : 1668553-26-1

Molecular Formula : C46H55N7O7S 

Molecular Weight : 850.05 

Iupac Chemical Name : A-1210477 

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SynonymsA-1210477; A 1210477; A1210477 
Molecular FormulaC46H55N7O7S 
Molecular Weight850.05 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines. A-1210477 synergizes with the BCL-2/BCL-XL inhibitor navitoclax to kill a variety of cancer cell lines. A-1210477 is a potential therapeutics for the treatment of cancer. The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. 

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