A-1210477
Catalog No.: 17022404
Cas No.: 1668553-26-1
Purity : 98%
Catalog number : 17022404
CAS number : 1668553-26-1
Molecular Formula : C46H55N7O7S
Molecular Weight : 850.05
Iupac Chemical Name : A-1210477
InChiKey :
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
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| Synonyms | A-1210477; A 1210477; A1210477 |
|---|---|
| Molecular Formula | C46H55N7O7S |
| Molecular Weight | 850.05 |
| Appearance | off-white solid |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Storage | 3 years -20ºCpowder |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
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A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines. A-1210477 synergizes with the BCL-2/BCL-XL inhibitor navitoclax to kill a variety of cancer cell lines. A-1210477 is a potential therapeutics for the treatment of cancer. The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target.
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