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4EGI-1

Catalog No: 102608
CAS Number: 315706-13-9
Purity: 98% 

4EGI-1 is a cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 M) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation.
 

For research use only. We do not sell to patients.

Chemical Information

Name4EGI-1
Iupac Chemical Name2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid 
SynonymseIF4E/eIF4G Interaction Inhibitor 
Molecular FormulaC18H16Cl2N4O4S 
Molecular Weight455.315 
SmileC1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-]
InChiKeyKFRKRECSIYXARE-UHFFFAOYSA-N
InChiInChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)
CAS Number315706-13-9
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Ordering Information

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FormulationSolid powder 
Purity98% 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

102608 - 4EGI-1 | CAS 315706-13-9

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