0990CL
Catalog No: 20562
CAS Number: 511514-03-7
Purity: 98% Min.
0990CL is an inhibitor of heterotrimeric Gαi subunits. 0990CL showed direct interaction with Gαi. Several compounds showed Gαi specific inhibition and were able to block α2AR mediated regulation of cAMP.
For research use only. We do not sell to patients.
Chemical Information
| Name | 0990CL |
|---|---|
| Iupac Chemical Name | (4-Phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine |
| Synonyms | 0990CL; 0990-CL; 0990 CL; |
| Molecular Formula | C21H21N5 |
| Molecular Weight | 343.42 |
| Smile | CC1(C)C=C(C)N=C(NC2=NC(C3=CC=CC=C3)=C4C=CC=CC4=N2)N1 |
| InChiKey | DXICUHJLOMNKOU-UHFFFAOYSA-N |
| InChi | InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26) |
| CAS Number | 511514-03-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Appleton KM, Bigham KJ, Lindsey CC, Hazard S, Lirjoni J, Parnham S, Hennig M, Peterson YK. Development of inhibitors of heterotrimeric Gαi subunits. Bioorg Med Chem. 2014 Jul 1;22(13):3423-34. doi: 10.1016/j.bmc.2014.04.035. Epub 2014 Apr 26. PMID: 24818958; PMCID: PMC4103618.
Chemical Structure
