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(+)-Apogossypol Catalog No : 61125

Chemical Information

Product Name(+)-Apogossypol
Iupac Chemical Name(+)-Apogossypol 
SynonymsApogossypol; NSC736630 
Molecular FormulaC28H30O6 
Molecular Weight462.53 
SmileCc1cc2c(cc(c(c2C(C)C)O)O)c(c1c3c(cc4c(c3O)cc(c(c4C(C)C)O)O)C)O
InChiKeyPBJKWGWHZVXBGU-UHFFFAOYSA-N
InChiInChI=1S/C28H30O6/c1-11(2)21-15-7-13(5)23(25(31)17(15)9-19(29)27(21)33)24-14(6)8-16-18(26(24)32)10-20(30)28(34)22(16)12(3)4/h7-12,29-34H,1-6H3
Cas66389-74-0
MDLMFCD23160033

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

(+)-Apogossypol(Apogossypol; NSC736630) is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 M.


 

Chemical Structure

61125 - (+)-Apogossypol | CAS 66389-74-0

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