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T-1095(RWJ-394718)

Catalog No.: 60302
Cas No.: 209746-59-8
Purity : 98% 
60302 - T-1095(RWJ-394718) | CAS 209746-59-8

Catalog number : 60302

CAS number : 209746-59-8

分子式 : C26H28O11 

分子量 : 516.49 

Iupac 化学名称 : ((2R,3S,4S,5R,6S)-6-(2-(3-(benzofuran-5-yl)propanoyl)-3-hydroxy-5-methylphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl methyl carbonate 

Smile : O=C(OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC(C)=CC(O)=C2C(CCC3=CC=C(OC=C4)C4=C3)=O)O1)OC

InChiKey : BXNCIERBDJYIQT-PRDVQWLOSA-N

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同义词T-1095;RWJ-394718;T1095;RWJ-394718;T1095;T 1095 
英文同义词T-1095;RWJ-394718;T1095;RWJ-394718;T1095;T 1095 
分子式C26H28O11 
分子量516.49 
外观pale yellow solid to off-white solid 
纯度98% 
可溶性Soluble in DMSO,THF,DCM 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileO=C(OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC(C)=CC(O)=C2C(CCC3=CC=C(OC=C4)C4=C3)=O)O1)OC
InChiKeyBXNCIERBDJYIQT-PRDVQWLOSA-N
InChiInChI=1S/C26H28O11/c1-13-9-17(28)21(16(27)5-3-14-4-6-18-15(11-14)7-8-34-18)19(10-13)36-25-24(31)23(30)22(29)20(37-25)12-35-26(32)33-2/h4,6-11,20,22-25,28-31H,3,5,12H2,1-2H3/t20-,22-,23+,24-,25-/m1/s1
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T-1095 is an inhibitor of renal Na+-glucose cotransporters, and it may provide a novel approach to treating diabetes.

References

*  Oku A1, Ueta K, Arakawa K, Ishihara T, Nawano M, Kuronuma Y, Matsumoto M, Saito A, Tsujihara K, Anai M, Asano T, Kanai Y, Endou H. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999 Sep;48(9):1794-800.  

*  Nunoi K1, Yasuda K, Adachi T, Okamoto Y, Shihara N, Uno M, Tamon A, Suzuki N, Oku A, Tsuda K. Beneficial effect of T-1095, a selective inhibitor of renal Na+-glucose cotransporters, on metabolic index and insulin secretion in spontaneously diabetic GK rats. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):386-90.

 

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