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Sorafenib

Catalog No.: 123017
Cas No.: 284461-73-0
Purity : 98% 
123017 - Sorafenib | CAS 284461-73-0

Catalog number : 123017

CAS number : 284461-73-0

分子式 : C21H16ClF3N4O3 

分子量 : 464.825 

Iupac 化学名称 : 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide 

Smile : CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChiKey : MLDQJTXFUGDVEO-UHFFFAOYSA-N

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同义词Nexavar; Bay 43-9006 
英文同义词Nexavar; Bay 43-9006 
分子式C21H16ClF3N4O3 
分子量464.825 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChiKeyMLDQJTXFUGDVEO-UHFFFAOYSA-N
InChiInChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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Sorafenib(BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro. 

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