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Navitoclax (ABT-263)

Catalog No.: 16070102
Cas No.: 923564-51-6
Purity : 98% by HPLC 
16070102 - Navitoclax (ABT-263) | CAS 923564-51-6

Catalog number : 16070102

CAS number : 923564-51-6

分子式 : C47H55ClF3N5O6S3 

分子量 : 974.61 

Iupac 化学名称 : (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide 

Smile : ClC1=CC=C(C=C1)C1=C(CC(CC1)(C)C)CN1CCN(CC1)C1=CC=C(C(=O)NS(=O)(=O)C2=CC(=C(C=C2)N[C@@H](CSC2=CC=CC=C2)CCN2CCOCC2)S(=O)(=O)C(F)(F)F)C=C1

InChiKey : JLYAXFNOILIKPP-KXQOOQHDSA-N

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同义词ABT 263; ABT-263 
英文同义词ABT 263; ABT-263 
分子式C47H55ClF3N5O6S3 
分子量974.61 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=CC=C(C=C1)C1=C(CC(CC1)(C)C)CN1CCN(CC1)C1=CC=C(C(=O)NS(=O)(=O)C2=CC(=C(C=C2)N[C@@H](CSC2=CC=CC=C2)CCN2CCOCC2)S(=O)(=O)C(F)(F)F)C=C1
InChiKeyJLYAXFNOILIKPP-KXQOOQHDSA-N
InChiInChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1
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Navitoclax, also known as ABT-263, is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. 

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