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Idasanutlin (RG7388)

编号: 16070812
Cas号: 1229705-06-9
纯度: 98% by HPLC 

Idasanutlin; also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. 

仅供研究使用。 我们不向患者出售。

化学信息

名称Idasanutlin (RG7388)
Iupac 化学名称4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid. 
同义词RG7388; RG 7388 
英文同义词RG7388; RG 7388 
分子式C31H29Cl2F2N3O4 
分子量616.48247 
InChiKey
InChi
Cas号1229705-06-9
相关CAS号

订购信息

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外观性状Solid powder 
纯度98% by HPLC 
存储-20 ºC for 3 years 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature 
海关编码
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16070812 - Idasanutlin (RG7388) | CAS 1229705-06-9

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