武汉永璨生物科技有限公司
+86-17702719238 sales@sun-shinechem.com

HLCL-61 HCl

编号: 16122819
Cas号: 1158279-20-9
纯度: 98% 

HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. 

仅供研究使用。 我们不向患者出售。

化学信息

名称HLCL-61 HCl
Iupac 化学名称HLCL-61 HCl 
同义词HLCL61; HLCL 61; HLCL-61 
英文同义词HLCL61; HLCL 61; HLCL-61 
分子式C23H25ClN2O 
分子量380.916 
InChiKey
InChi
Cas号1158279-20-9
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122819 - HLCL-61 HCl | CAS 1158279-20-9

快速订购

Change