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FF-10101

Catalog No.: 512192
Cas No.: 1472797-69-5
Purity : 98% Min.
512192 - FF-10101 | CAS 1472797-69-5

Catalog number : 512192

CAS number : 1472797-69-5

分子式 : C29H38N8O2

分子量 : 530.66

Iupac 化学名称 : ((S,E)-N-{1-[(5-{2-[(4-cyanophenyl)amino]-4-(propylamino)pyrimidin-5-yl}pent-4-yn-1-yl)amino]-1-oxopropan-2-yl}-4-(dimethylamino)-N-methylbut-2-enamide), ((S,E)-N-(1-(5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide, (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methyl-2-butenamide

Smile : O=C(N([C@@H](C)C(NCCCC#CC1=CN=C(NC2=CC=C(C#N)C=C2)N=C1NCCC)=O)C)/C=C/CN(C)C

InChiKey : HJFSVYUFOXAVAA-YUAYGMJFSA-N

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同义词FF-10101; FF10101;FF 10101
英文同义词FF-10101; FF10101;FF 10101
分子式C29H38N8O2
分子量530.66
外观 类白色至白色固体
纯度98% Min.
可溶性可溶于DMSO
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileO=C(N([C@@H](C)C(NCCCC#CC1=CN=C(NC2=CC=C(C#N)C=C2)N=C1NCCC)=O)C)/C=C/CN(C)C
InChiKeyHJFSVYUFOXAVAA-YUAYGMJFSA-N
InChiInChI=1S/C29H38N8O2/c1-6-17-31-27-24(21-33-29(35-27)34-25-15-13-23(20-30)14-16-25)11-8-7-9-18-32-28(39)22(2)37(5)26(38)12-10-19-36(3)4/h10,12-16,21-22H,6-7,9,17-19H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b12-10+/t22-/m0/s1

FF-10101 is a FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) inhibitor, with potential antineoplastic activity.Upon administration of FLT3 inhibitor FF-10101 succinate (FF-10101-01), FF-10101 irreversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. Check for active clinical trials using this agent. (NCI Thesaurus)


Sun-shine Chemical has completed the synthesis of FF-10101. and we may provide the product to clients with high quality and  competitive price for your research.

1.Wu M, Li C, Zhu X.,FLT3 inhibitors in acute myeloid leukemia.

J Hematol Oncol. 2018 Dec 4;11(1):133. doi: 10.1186/s13045-018-0675-4. 

2. Yamaura T, Nakatani T, Uda K, etc.

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations.

Blood. 2018 Jan 25;131(4):426-438. doi: 10.1182/blood-2017-05-786657. Epub 2017 Nov 29.


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