Deguelin
编号: 16122701
Cas号: 522-17-8
纯度: 98%
Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor.Deguelin increases sensitivity of human leukaemia cells to chemotherapeutic drugs. Deguelin dephosphorylates Akt and increases cytarabine sensitivity of AML blasts but not of CB CD34+. Deguelin, when employed for 24 h at 10 nmol/l, causes an S phase arrest of U937 cells, with interference of progression to G2/M phase. While employed alone up to a concentration of 10 nmol/l for 24 h, Deguelin does not significantly increase the apoptotic rate of U937 cells
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Deguelin |
|---|---|
| Iupac 化学名称 | Deguelin |
| 同义词 | (-)-Deguelin, (-)-cis-Deguelin |
| 英文同义词 | (-)-Deguelin, (-)-cis-Deguelin |
| 分子式 | C23H22O6 |
| 分子量 | 469.54 |
| Smile | CC1(C=Cc2c(ccc3c2O[C@@H]4COc5cc(c(cc5[C@@H]4C3=O)OC)OC)O1)C |
| InChiKey | ORDAZKGHSNRHTD-UXHICEINSA-N |
| InChi | InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1 |
| Cas号 | 522-17-8 |
| MDL | MFCD01740600 |
| 相关CAS号 |
订购信息
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