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Dacomitinib

Catalog No.: 52211
Cas No.: 1110813-31-4
Purity : 98% 
52211 - Dacomitinib | CAS 1110813-31-4

Catalog number : 52211

CAS number : 1110813-31-4

分子式 : C24H25ClFN5O2 

分子量 : 469.94 

Iupac 化学名称 : (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide 

Smile : O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4

InChiKey : LVXJQMNHJWSHET-AATRIKPKSA-N

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同义词PF299804;PF299. 
英文同义词PF299804;PF299. 
分子式C24H25ClFN5O2 
分子量469.94 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4
InChiKeyLVXJQMNHJWSHET-AATRIKPKSA-N
InChiInChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
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PF-299804 is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM, effective against NSCLCs with EGFR or ERBB2 mutations (resistant to gefitinib) as well as those harboring the EGFR T790M mutation. Phase 2 

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