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AZ 628

Catalog No.: 011120
Cas No.: 878739-06-1
Purity : 98% 
011120 - AZ 628 | CAS 878739-06-1

Catalog number : 011120

CAS number : 878739-06-1

分子式 : C27H25N5O2 

分子量 : 451.520 

Iupac 化学名称 : 3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide 

Smile : CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

InChiKey : ZGBGPEDJXCYQPH-UHFFFAOYSA-N

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同义词AZ-628; AZ628 
英文同义词AZ-628; AZ628 
分子式C27H25N5O2 
分子量451.520 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
InChiKeyZGBGPEDJXCYQPH-UHFFFAOYSA-N
InChiInChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
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AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. 

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