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AV-412(MP-412)

Catalog No.: 100501
Cas No.: 451493-31-5(tosylate);451492-95-8(free-base)
Purity : 99.48% by HPLC at 254nm 
100501 - AV-412(MP-412) | CAS 451493-31-5(tosylate);451492-95-8(free-base)

Catalog number : 100501

CAS number : 451493-31-5(tosylate);451492-95-8(free-base)

分子式 : C41H44ClFN6O7S2 

分子量 : 507.00 

Iupac 化学名称 : N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate) 

Smile : C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1C#CC(N4CCN(C)CC4)(C)C)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O=S(C6=CC=C(C)C=C6)(O)=O

InChiKey : GTWJVFFZCKODEV-UHFFFAOYSA-N

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同义词MP-412;MP 412;MP412;AV-412;AV 412;AV412. 
英文同义词MP-412;MP 412;MP412;AV-412;AV 412;AV412. 
分子式C41H44ClFN6O7S2 
分子量507.00 
外观yellow solid 
纯度99.48% by HPLC at 254nm 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileC=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1C#CC(N4CCN(C)CC4)(C)C)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O=S(C6=CC=C(C)C=C6)(O)=O
InChiKeyGTWJVFFZCKODEV-UHFFFAOYSA-N
InChiInChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10)
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AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Check for active clinical trials using this agent. (NCI Thesaurus)

 

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