AV-412(MP-412)
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Catalog number : 100501
CAS number : 451493-31-5(tosylate);451492-95-8(free-base)
分子式 : C41H44ClFN6O7S2
分子量 : 507.00
Iupac 化学名称 : N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate)
Smile : C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1C#CC(N4CCN(C)CC4)(C)C)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O=S(C6=CC=C(C)C=C6)(O)=O
InChiKey : GTWJVFFZCKODEV-UHFFFAOYSA-N
| Packaging | Price | Availability | Purity | Estimated Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry |
| 同义词 | MP-412;MP 412;MP412;AV-412;AV 412;AV412. |
|---|---|
| 英文同义词 | MP-412;MP 412;MP412;AV-412;AV 412;AV412. |
| 分子式 | C41H44ClFN6O7S2 |
| 分子量 | 507.00 |
| 外观 | yellow solid |
| 纯度 | 99.48% by HPLC at 254nm |
| 可溶性 | Soluble in DMSO |
| 存储 | 3 years -20ºCpowder 6 months-80ºCin solvent |
| 运输条件 | Shipped under ambient temperature |
| Smile | C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1C#CC(N4CCN(C)CC4)(C)C)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O=S(C6=CC=C(C)C=C6)(O)=O |
| InChiKey | GTWJVFFZCKODEV-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10) |
AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Check for active clinical trials using this agent. (NCI Thesaurus)
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