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AICAR phosphate 编号 : 611809

化学信息

产品英文名称AICAR phosphate
Iupac 化学名称AICAR (phosphate) 
同义词Acadesine phosphate; AICA Riboside phosphate 
英文同义词Acadesine phosphate; AICA Riboside phosphate 
分子式C9H17N4O9P 
分子量356.23 
InChiKey
InChi
Cas681006-28-0

技术数据

外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
质量控制

产品详情

AICAR phosphate (Acadesine), is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

AICAR, also known as 5-aminoimidazole-4-carboxamide-1--D-ribofuranoside, AICA-riboside, and Acadesine, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis. Acadesine acts as an AMP-activated protein kinase agonist. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases and in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.

 

结构

611809 - AICAR phosphate | CAS 681006-28-0

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