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ZL0454

Catalog No.: 193281
Cas No.: 2229042-77-5
Purity : >98%
193281 - ZL0454  | CAS 2229042-77-5

Catalog number : 193281

CAS number : 2229042-77-5

Molecular Formula : C18H22N4O3S

Molecular Weight : 374.46

Iupac Chemical Name : (E)-4-((2-Amino-4-hydroxy-5-methylphenyl)diazenyl)-N-cyclopentylbenzenesulfonamide

Smile : O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3CCCC3)=O

InChiKey : IRKMSULWLDLTIK-QZQOTICOSA-N

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SynonymsZL-0454; ZL 0454; ZL0454
Molecular FormulaC18H22N4O3S
Molecular Weight374.46
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileO=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3CCCC3)=O
InChiKeyIRKMSULWLDLTIK-QZQOTICOSA-N
InChiInChI=1S/C18H22N4O3S/c1-12-10-17(16(19)11-18(12)23)21-20-13-6-8-15(9-7-13)26(24,25)22-14-4-2-3-5-14/h6-11,14,22-23H,2-5,19H2,1H3/b21-20+
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ZL0454 is a potent and selective BRD4 inhibitor. ZL0454 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program, including ISG54, ISG56, IL-8, and Groβ genes in cultured human small airway epithelial cells (hSAECs).

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