YM-155 hydrochloride
Catalog No: 6111414
CAS Number: 355406-09-6
Purity: 98%
YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
YM155 completely inhibits the tumor growth of PC-3 s.c. xenografted prostate tumors at doses of 3 and 10 mg/kg, without body weight loss and blood cell count decrease. Pharmacokinetic analysis shows that YM155 is highly distributed to tumor tissue. Moreover, YM155 shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts. The combination therapy with YM155 and -radiation shows great antitumor activity against H460 or Calu6 xenografts in nude mice.
For research use only. We do not sell to patients.
Chemical Information
| Name | YM-155 hydrochloride |
|---|---|
| Iupac Chemical Name | YM-155 hydrochloride |
| Synonyms | YM155 hydrochloride; YM 155 hydrochloride |
| Molecular Formula | C20H19ClN4O3 |
| Molecular Weight | 398.84 |
| Smile | Cc1n(c2c([n+]1Cc3cnccn3)C(=O)c4ccccc4C2=O)CCOC.[Cl-] |
| InChiKey | NUZWGSASIPTGSA-UHFFFAOYSA-M |
| InChi | InChI=1S/C20H19N4O3.ClH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1 |
| CAS Number | 355406-09-6 |
| MDL | MFCD18207200 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
