Welcome to Sun-shine chemical
+86-17702719238 sales@sun-shinechem.com

VE-822 ( Berzosertib )

Catalog No: 51607
CAS Number: 1232416-25-9
Purity: ≧98.0% 

VE-822(Berzosertib), an analogue of VE-821 with increased potency and selectivity against ATR, increased solubility and good pharmacokinetic properties was shown to potently radiosensitise pancreatic cancer cell lines in vitro.VE-822 was the first selective ATR inhibitor to enter clinical development, and is now known as VX-970. In a recent study, published by Vertex Pharmaceuticals, VX-970 (VE-822) was shown to markedly sensitise a panel of non-small cell lung cancer cell lines, but not normal cells, to multiple DNA damaging drugs, namely cisplatin, oxaliplatin, gemcitabine, etoposide and SN38, the active metabolite of irinotecan.

For research use only. We do not sell to patients.

Chemical Information

NameVE-822 ( Berzosertib )
Iupac Chemical Name 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine
SynonymsVE-822,VX-970;VE822;VE 822;Berzosertib; M6620; M-6620; M 6620;
Molecular FormulaC24H25N5O3S 
Molecular Weight463.55 
SmileCNCC1=CC=C(C=C1)C1=NOC(=C1)C=1C(=NC=C(N1)C1=CC=C(C=C1)S(=O)(=O)C(C)C)N
InChiKeyJZCWLJDSIRUGIN-UHFFFAOYSA-N
InChiInChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
CAS Number1232416-25-9
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
Formulationyellow solid 
Purity≧98.0% 
Storage3 years -20ºCpowder 
Solubility5mg/ml in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

51607 - VE-822 ( Berzosertib ) | CAS 1232416-25-9

Quick Order

Change