TAK-580 (MLN2480)
Catalog No: 16062203
CAS Number: 1096708-71-2
Purity: 98% by HPLC
TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.
For research use only. We do not sell to patients.
Chemical Information
| Name | TAK-580 (MLN2480) |
|---|---|
| Iupac Chemical Name | (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide |
| Synonyms | TAK580; MLN 2480 |
| Molecular Formula | C17H12Cl2F3N7O2S |
| Molecular Weight | 506.29 |
| Smile | NC1=C(C(=NC=N1)C(=O)N[C@H](C)C=1SC(=CN1)C(=O)NC1=NC=C(C(=C1)C(F)(F)F)Cl)Cl |
| InChiKey | VWMJHAFYPMOMGF-ZCFIWIBFSA-N |
| InChi | InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1 |
| CAS Number | 1096708-71-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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