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SKI II

Catalog No.: 6111526
Cas No.: 312636-16-1
Purity : 98% 
6111526 - SKI II | CAS 312636-16-1

Catalog number : 6111526

CAS number : 312636-16-1

Molecular Formula : C15H11ClN2OS 

Molecular Weight : 302.78 

Iupac Chemical Name : SKI II 

Smile : c1cc(ccc1c2csc(n2)Nc3ccc(cc3)O)Cl

InChiKey : ZFGXZJKLOFCECI-UHFFFAOYSA-N

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SynonymsSKI-II 
Molecular FormulaC15H11ClN2OS 
Molecular Weight302.78 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1cc(ccc1c2csc(n2)Nc3ccc(cc3)O)Cl
InChiKeyZFGXZJKLOFCECI-UHFFFAOYSA-N
InChiInChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
MDLMFCD00733553
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SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 M for SK1 and 45 M for SK2.

SKI II inhibits cell proliferation by suppressing the Wnt/-catenin signaling pathway. SKI II also reduces the expression of c-Myc and cyclin D1, the downstream target genes of the Wnt signaling pathway. SKI II inhibits cell proliferation by suppressing the Wnt/-catenin signaling pathway. SKI II promotes the degradation of -catenin by enhancing Wnt5A. SKI II inhibits the proliferation of HepG2 cells by blocking the Wnt/-catenin signaling pathway.

SKI-II causes an irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. In the present study, SKI-II was administered 3-weekly i.p. to LDL-R-/- mice for 16 weeks at a dose previously demonstrated to reduce tumor growth in mice. Preliminary experiments revealed that a single administration of SKI-II produces a significant reduction of plasma S1P with the maximum (40%) observed 12 h after injection.

 

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