SHP099 free base
Catalog No: 17030107
CAS Number: 1801747-42-1
Purity: 98%
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 M and p-ERK modulation in cells IC50 = 0.250 M. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1).
For research use only. We do not sell to patients.
Chemical Information
| Name | SHP099 free base |
|---|---|
| Iupac Chemical Name | SHP099 free base |
| Synonyms | SHP099; SHP-099; SHP 099 |
| Molecular Formula | C16H19Cl2N5 |
| Molecular Weight | 352.263 |
| InChiKey | |
| InChi | |
| CAS Number | 1801747-42-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
