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SHP099 free base

Catalog No.: 17030107
Cas No.: 1801747-42-1
Purity : 98% 
17030107 - SHP099 free base | CAS 1801747-42-1

Catalog number : 17030107

CAS number : 1801747-42-1

Molecular Formula : C16H19Cl2N5 

Molecular Weight : 352.263 

Iupac Chemical Name : SHP099 free base 

InChiKey :

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SynonymsSHP099; SHP-099; SHP 099 
Molecular FormulaC16H19Cl2N5 
Molecular Weight352.263 
Appearanceoff-white solid 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 M and p-ERK modulation in cells IC50 = 0.250 M. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). 

1801747-42-1 - Request Bulk Quote

1801747-42-1 - Request Bulk Quote