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Miransertib(ARQ 092)

Catalog No: 17021301
CAS Number: 1313883-00-9
Purity: 98% 

ARQ 092 is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.

ARQ 092 blocks membrane translocation of inactive AKT and even dephosphorylates the membrane-associated active form, thereby perturbing AKT activity. Treatment with 50-500 nM ARQ 092 significantly blocks M2 integrin function in neutrophils and reduces P-selectin exposure and glycoprotein Ib/IX/V-mediated agglutination in platelets[2]. In a large panel of diverse cancer cell lines, ARQ 092 inhibits proliferation across multiple tumor types but are most potent in leukemia, breast, endometrial, and colorectal cancer cell lines. Moreover, inhibition by ARQ 092 is more prevalent in cancer cell lines containing PIK3CA/PIK3R1 mutations compared to those with wt-PIK3CA/PIK3R1 or PTEN mutations[1]. ARQ 092 targets the PI3K/AKT pathway and AKT specifically and reduces phosphorylation of GSK3 and GSK3 in mutation-positive cells[3].

 

For research use only. We do not sell to patients.

Chemical Information

NameMiransertib(ARQ 092)
Iupac Chemical Name3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine 
SynonymsARQ092; ARQ-092; ARQ 092; Miransertib 
Molecular FormulaC27H25ClN6 
Molecular Weight468.98 
SmileNC1(CCC1)C1=CC=C(C=C1)N1C(=NC=2C1=NC(=CC2)C2=CC=CC=C2)C=2C(=NC=CC2)N
InChiKeyHNFMVVHMKGFCMB-UHFFFAOYSA-N
InChiInChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30)
CAS Number1313883-00-9
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17021301 - Miransertib(ARQ 092) | CAS 1313883-00-9

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