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KU 57788

Catalog No: 160926003
CAS Number: 503468-95-9
Purity: 98% by HPLC 

Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin andetoposidein vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%. 

For research use only. We do not sell to patients.

Chemical Information

NameKU 57788
Iupac Chemical Name8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one 
SynonymsNU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. 
Molecular FormulaC25H19NO3S 
Molecular Weight413.49 
SmileC1=CC=C(C=2SC3=C(C21)C=CC=C3)C3=CC=CC=2C(C=C(OC23)N2CCOCC2)=O
InChiKeyJAMULYFATHSZJM-UHFFFAOYSA-N
InChiInChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
CAS Number503468-95-9
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

160926003 - KU 57788 | CAS 503468-95-9

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