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INCB3344

Catalog No: 185215
CAS Number: 1262238-11-8
Purity: >98%

INCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.

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Chemical Information

NameINCB3344
Iupac Chemical NameN-(2-(((3S,4S)-1-(4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
SynonymsINCB3344; INCB-3344; INCB 3344.
Molecular FormulaC29H34F3N3O6
Molecular Weight577.6012
SmileO=C(NCC(N[C@H]1CN(C2CCC(O)(C3=CC=C(OCO4)C4=C3)CC2)C[C@@H]1OCC)=O)C5=CC=CC(C(F)(F)F)=C5
InChiKeyMZEOSVPWMSEFPW-XYCDVDSTSA-N
InChiInChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21?,22-,25-,28?/m0/s1
CAS Number1262238-11-8
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid to white solid
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

185215 - INCB3344 | CAS 1262238-11-8

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