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Deguelin

Catalog No.: 16122701
Cas No.: 522-17-8
Purity : 98% 

Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor.Deguelin increases sensitivity of human leukaemia cells to chemotherapeutic drugs. Deguelin dephosphorylates Akt and increases cytarabine sensitivity of AML blasts but not of CB CD34+. Deguelin, when employed for 24 h at 10 nmol/l, causes an S phase arrest of U937 cells, with interference of progression to G2/M phase. While employed alone up to a concentration of 10 nmol/l for 24 h, Deguelin does not significantly increase the apoptotic rate of U937 cells 

For research use only. We do not sell to patients.

Chemical Information

NameDeguelin
Iupac Chemical NameDeguelin 
Synonyms(-)-Deguelin, (-)-cis-Deguelin 
Molecular FormulaC23H22O6 
Molecular Weight469.54 
SmileCC1(C=Cc2c(ccc3c2O[C@@H]4COc5cc(c(cc5[C@@H]4C3=O)OC)OC)O1)C
InChiKeyORDAZKGHSNRHTD-UXHICEINSA-N
InChiInChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1
CAS Number522-17-8
MDLMFCD01740600
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122701 - Deguelin | CAS 522-17-8

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