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Deguelin

Catalog No.: 16122701
Cas No.: 522-17-8
Purity : 98% 
16122701 - Deguelin | CAS 522-17-8

Catalog number : 16122701

CAS number : 522-17-8

Molecular Formula : C23H22O6 

Molecular Weight : 469.54 

Iupac Chemical Name : Deguelin 

Smile : CC1(C=Cc2c(ccc3c2O[C@@H]4COc5cc(c(cc5[C@@H]4C3=O)OC)OC)O1)C

InChiKey : ORDAZKGHSNRHTD-UXHICEINSA-N

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Synonyms(-)-Deguelin, (-)-cis-Deguelin 
Molecular FormulaC23H22O6 
Molecular Weight469.54 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC1(C=Cc2c(ccc3c2O[C@@H]4COc5cc(c(cc5[C@@H]4C3=O)OC)OC)O1)C
InChiKeyORDAZKGHSNRHTD-UXHICEINSA-N
InChiInChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1
MDLMFCD01740600
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Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an PI3K/AKT Inhibitor.Deguelin increases sensitivity of human leukaemia cells to chemotherapeutic drugs. Deguelin dephosphorylates Akt and increases cytarabine sensitivity of AML blasts but not of CB CD34+. Deguelin, when employed for 24 h at 10 nmol/l, causes an S phase arrest of U937 cells, with interference of progression to G2/M phase. While employed alone up to a concentration of 10 nmol/l for 24 h, Deguelin does not significantly increase the apoptotic rate of U937 cells 

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