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Dabrafenib mesylate

Catalog No: 16122807
CAS Number: 1195768-06-9
Purity: 98%

Dabrafenib mesylate, also known as GSK 2118436B, is a potent and orally active B-raf (BRAF) inhibitor with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type

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Chemical Information

NameDabrafenib mesylate
Iupac Chemical NameDabrafenib mesylate
SynonymsGSK 2118436B; GSK2118436B; GSK-2118436B; GSK2118436 Methane sulfonate salt; Brand name: Taflinar.
Molecular FormulaC24H24F3N5O5S3
Molecular Weight615.6612
SmileCC(C)(C)c1nc(c(s1)c2ccnc(n2)N)c3cccc(c3F)NS(=O)(=O)c4c(cccc4F)F.CS(=O)(=O)O
InChiKeyYKGMKSIHIVVYKY-UHFFFAOYSA-N
InChiInChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)
CAS Number1195768-06-9
MDLMFCD20922872
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Ordering Information

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Formulationcrystalline solid
Purity98%
Storage3 years -20℃powder
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122807 - Dabrafenib mesylate | CAS 1195768-06-9

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