Ciliobrevin A
Catalog No: 16122921
CAS Number: 302803-72-1
Purity: 98%
Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway.
For research use only. We do not sell to patients.
Chemical Information
| Name | Ciliobrevin A |
|---|---|
| Iupac Chemical Name | Ciliobrevin A |
| Synonyms | HPI-4; HPI 4; HPI4. Hedgehog Pathway Inhibitor 4 |
| Molecular Formula | C17H9Cl2N3O2 |
| Molecular Weight | 358.178 |
| Smile | c1ccc2c(c1)C(=O)N/C(=C(\C#N)/C(=O)c3ccc(cc3Cl)Cl)/N2 |
| InChiKey | SESYPWCSIZUIAS-FOWTUZBSSA-N |
| InChi | InChI=1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12+ |
| CAS Number | 302803-72-1 |
| MDL | MFCD01911757 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
