+86-27-65522453 sales@sun-shinechem.com

Ciliobrevin A

Catalog No.: 16122921
Cas No.: 302803-72-1
Purity : 98% 
16122921 - Ciliobrevin A | CAS 302803-72-1

Catalog number : 16122921

CAS number : 302803-72-1

Molecular Formula : C17H9Cl2N3O2 

Molecular Weight : 358.178 

Iupac Chemical Name : Ciliobrevin A 

Smile : c1ccc2c(c1)C(=O)N/C(=C(\C#N)/C(=O)c3ccc(cc3Cl)Cl)/N2

InChiKey : SESYPWCSIZUIAS-FOWTUZBSSA-N

PackagingPriceAvailabilityPurityEstimated Shipping Time
BulkEnquiryEnquiry
Request Bulk Quote Download MSDSTel:+86-27-65522453 | Email:sales@sun-shinechem.com
SynonymsHPI-4; HPI 4; HPI4. Hedgehog Pathway Inhibitor 4 
Molecular FormulaC17H9Cl2N3O2 
Molecular Weight358.178 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc2c(c1)C(=O)N/C(=C(\C#N)/C(=O)c3ccc(cc3Cl)Cl)/N2
InChiKeySESYPWCSIZUIAS-FOWTUZBSSA-N
InChiInChI=1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12+
MDLMFCD01911757
Coming soon.
Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway. 

302803-72-1 - Request Bulk Quote

×
302803-72-1 - Request Bulk Quote
Change