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Alvelestat (AZD9688) Catalog No : 16122854

Chemical Information

Product NameAlvelestat (AZD9688)
Iupac Chemical NameAlvelestat (AZD9688) 
SynonymsAZD9668; AZD 9668; AZD-9668; Alvelestat 
Molecular FormulaC25H22F3N5O4S 
Molecular Weight545.53 
InChiKey
InChi
Cas848141-11-7

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE), an enzyme implicated in the signs, symptoms, and disease progression in NE-driven respiratory diseases such as bronchiectasis and chronic obstructive pulmonary disease via its role in the inflammatory process, mucus overproduction, and lung tissue damage. In cell-based assays, AZD9668 inhibited plasma NE activity in zymosan-stimulated whole blood. AZD9668 has the potential to reduce lung inflammation and the associated structural and functional changes in human diseases. 

Chemical Structure

16122854 - Alvelestat (AZD9688) | CAS 848141-11-7

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