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Afatinib (BIBW2992) Catalog No : 52761

Chemical Information

Product NameAfatinib (BIBW2992)
Iupac Chemical Name(S,E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide 
Molecular FormulaC24H25ClFN5O3 
Molecular Weight485.94 
SmileClC=1C=C(C=CC1F)NC1=NC=NC2=CC(=C(C=C12)NC(\C=C\CN(C)C)=O)O[C@@H]1COCC1
InChiKeyULXXDDBFHOBEHA-CWDCEQMOSA-N
InChiInChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
Cas439081-18-2

Technical Data

Purity98% 
Quality control

Description

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt)EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. 

Chemical Structure

52761 - Afatinib (BIBW2992) | CAS 439081-18-2

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