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AV-412(MP-412) Catalog No : 100501

Chemical Information

Product NameAV-412(MP-412)
Iupac Chemical NameN-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate) 
SynonymsMP-412;MP 412;MP412;AV-412;AV 412;AV412. 
Molecular FormulaC41H44ClFN6O7S2 
Molecular Weight507.00 
SmileC=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1C#CC(N4CCN(C)CC4)(C)C)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O=S(C6=CC=C(C)C=C6)(O)=O
InChiKeyGTWJVFFZCKODEV-UHFFFAOYSA-N
InChiInChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10)
Cas451493-31-5(tosylate);451492-95-8(free-base)

Technical Data

Appearanceyellow solid 
Purity99.48% by HPLC at 254nm 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Check for active clinical trials using this agent. (NCI Thesaurus)

 

Chemical Structure

100501 - AV-412(MP-412) | CAS 451493-31-5(tosylate);451492-95-8(free-base)

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