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AICAR phosphate Catalog No : 611809

Chemical Information

Product NameAICAR phosphate
Iupac Chemical NameAICAR (phosphate) 
SynonymsAcadesine phosphate; AICA Riboside phosphate 
Molecular FormulaC9H17N4O9P 
Molecular Weight356.23 
InChiKey
InChi
Cas681006-28-0

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

AICAR phosphate (Acadesine), is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

AICAR, also known as 5-aminoimidazole-4-carboxamide-1--D-ribofuranoside, AICA-riboside, and Acadesine, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis. Acadesine acts as an AMP-activated protein kinase agonist. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases and in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.

 

Chemical Structure

611809 - AICAR phosphate | CAS 681006-28-0

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