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(±)-Bisoprolol hemifumarate

Catalog No: 6111106
CAS Number: 104344-23-2
Purity: 98% 

Bisoprolol is a selective type 1 adrenergic receptor blocker.

Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol [1]. Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) .


 

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Chemical Information

Name(±)-Bisoprolol hemifumarate
Iupac Chemical Name (±)-Bisoprolol hemifumarate
SynonymsBisoprolol hemifumarate salt 
Molecular FormulaC40H66N2O12 
Molecular Weight766.96 
SmileCC(C)NC[C@H](COc1ccc(cc1)COCCOC(C)C)O
InChiKeyVHYCDWMUTMEGQY-QGZVFWFLSA-N
InChiInChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3/t17-/m1/s1
CAS Number104344-23-2
MDLMFCD08063387
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20&ordm;Cpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

6111106 - (±)-Bisoprolol hemifumarate | CAS 104344-23-2

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