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Encorafenib(LGX-818)

Catalog No: 179308
CAS Number: 1269440-17-6
Purity: >98%

Encorafenib, also known as LGX818 is a drug candidate for the treatment of melanoma with the V600E mutation in the B-RAF kinase. The substance is being developed by Novartis and was disclosed at the spring 2013 American Chemical Society meeting in New Orleans.

For research use only. We do not sell to patients.

Chemical Information

NameEncorafenib(LGX-818)
Iupac Chemical Name(S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate
Synonyms Encorafenib;LGX818; LGX-818; LGX 818;
Molecular FormulaC22H27ClFN7O4S
Molecular Weight540.01
SmileO=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1
InChiKeyCMJCXYNUCSMDBY-ZDUSSCGKSA-N
InChi InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1
CAS Number1269440-17-6
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationoff-white solid
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO, not in water
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
HS Code
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

179308 - Encorafenib(LGX-818) | CAS 1269440-17-6

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